Reproxalap turned down for a third time
Rejected by FDA
The FDA again declined to approve Aldeyra’s reproxalap drop for dry eye, pointing to study results that didn’t line up with each other.
Source: Fierce Biotech, March 2026 (opens in a new tab)Symvana is an independent guide to dry, tired and screen-strained eyes. Take a three-minute quiz to see what’s most likely behind your symptoms and which drops, masks and treatments the research actually supports.
Free, no sign-up, and your answers stay on your device.
Blink. The oil layer spreads back over the eye.
16.4M million
US adults have been diagnosed with dry eye. Many more call it tired eyes and never get it checked.
Farrand et al., 2017 (opens in a new tab)86%
of people with dry eye in a large clinic study showed signs of struggling oil glands in their eyelids. Watery drops alone can’t fix that.
Lemp et al., 2012 (opens in a new tab)4.5
blinks a minute while reading, down from about 17 at rest. On screens, more of those blinks only close halfway.
Bentivoglio et al., 1997 (opens in a new tab)Dry eye isn’t one problem. It’s a failure in one or more layers of a film far thinner than a hair. Knowing which layer is struggling is the difference between relief and another half-used bottle in the drawer.
Fig. 2 The tear film in cross-section. Not to scale: the water layer is many times thicker than the oil layer above it.
A film of oils, thinner than a soap bubble, that slows evaporation. When it runs thin, the water beneath it evaporates in seconds. This is the most common reason for dry eye.
The bulk of the tear film. It keeps the surface of the eye wet, washes away debris and carries proteins that fight infection. When your glands don’t make enough, the whole film thins.
A slippery, gel-like layer that lets the watery tears cling to the eye instead of beading up and running off. Without it, tears can’t spread evenly and patches of the surface dry out.
Fifteen questions about your symptoms, habits, health and surroundings. The Dry Eye Profile weighs them the way an eye doctor works through a history, then shows which layer is likely struggling and what to try first.
Example result
Oil layer, leaning evaporative
Your first three moves
Everything runs in your browser. Nothing to install, and your camera feed never leaves your device.
Read a short passage while your webcam counts your full and half blinks. Takes 60 seconds, and shows how your rate compares with resting and reading averages.
Average blinks per minute in healthy adults, from Bentivoglio et al., 1997.
Take the Blink Test20-20-20 reminders that keep firing when the tab is in the background, with a guided 20-second break.
Start a timerPaste the ingredients from any eye drop box. See what each one does, which preservatives to watch and whether it suits your type.
Decode a labelEvery remedy gets an evidence grade, and every grade links to its source. Some popular ones don’t make the cut.
| Remedy | Where | Evidence | Cost |
|---|---|---|---|
| Preservative-free artificial tearsThe sensible first step for almost everyone. Pick preservative-free if you use drops more than four times a day, and match the formula to your type.Pucker et al., Cochrane Database of Systematic Reviews, 2016 (opens in a new tab) | Over the counter | Good | $About $10 to $25 a month |
| Warm compress with a heat-holding maskSoftens thickened oil in the eyelid glands, but only if the heat stays above about 40°C for around ten minutes. A microwaved mask does that. A washcloth doesn’t.Review of warm compress therapy in MGD, 2024 (opens in a new tab) | At home | Good | $One-off $15 to $35 |
| Blink exercisesA small trial found a month of simple blink drills improved symptoms and tear film stability. Promising, free and takes two minutes.Kim et al., Contact Lens & Anterior Eye, 2021 (opens in a new tab) | At home | Mixed | Free |
| Omega-3 fish oil supplementsThe largest trial gave people 3,000 mg a day for a year. They did no better than people taking olive oil.DREAM Study Research Group, New England Journal of Medicine, 2018 (opens in a new tab) | Over the counter | Mixed | $$About $15 to $45 a month |
| Blue light glasses for eye strainA 2023 Cochrane review found they probably make no difference to eye strain from screens. Spend the money elsewhere.Singh et al., Cochrane Database of Systematic Reviews, 2023 (opens in a new tab) | Over the counter | Weak | $$About $20 to $100 |
| Lotilaner (Xdemvy) for DemodexTwo phase 3 trials. In one, 56% of patients had their lash debris fully cleared after six weeks, against 12.5% on placebo.Saturn-2 phase 3 trial, Ophthalmology, 2023 (opens in a new tab) | Prescription | Strong | $$$Varies with insurance |
| Intense pulsed light (IPL)Pulses of light on the skin below the eyes improve oil gland function and tear stability. Especially useful if you also have rosacea.Healio, April 2021 (opens in a new tab) | In a clinic | Good | $$$$Often $300 to $600 a session, usually 3 to 4 sessions |
New approvals, rejections and studies, translated into what they mean for your eyes. Updated as the science moves.
Rejected by FDA
The FDA again declined to approve Aldeyra’s reproxalap drop for dry eye, pointing to study results that didn’t line up with each other.
Source: Fierce Biotech, March 2026 (opens in a new tab)Expert consensus
The Tear Film & Ocular Surface Society published TFOS DEWS III, its third global report on dry eye. Symptoms are now a required part of the diagnosis, and nerve problems are named as a cause alongside inflammation and tear instability.
Source: Association of Optometrists news, June 2025 (opens in a new tab)FDA approved
Alcon’s Tryptyr (acoltremon) became the first approved dry eye drop to target TRPM8, the nerve receptor that senses cooling and helps trigger tearing.
Source: Alcon press release, May 2025 (opens in a new tab)Blocked oil glands, eyelid mites and long-running inflammation don’t respond to anything on a pharmacy shelf. A dry eye specialist can measure what’s going on and treat the cause.